Improvements in pain and function were maintained with MACI at year 5.MACI is used for the repair of symptomatic cartilage damage of the adult knee.The amount of MACI applied depends on the size of the cartilage damage. Vericel websites use cookies, small text files stored on your browser, to personalize your web experience and to analyze website traffic. The implantation of MACI is to be performed via an arthrotomy to the knee joint under sterile conditions.The amount of MACI administered is dependent upon the size (surface in cm²) of the cartilage defect. Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial. Step 3 of 6: your own cells
Vericel websites use cookies, small text files stored on your browser, to personalize your web experience and to analyze website traffic. This means your cartilage injury could get worse over time, leaving you with more pain and limiting your physical activity.MACI uses your own cells to repair your knee cartilage damage.At the facility, your cartilage cells will be treated to help them expand and multiply.The membrane will be customized to match the size and shape of your cartilage defect before it is affixed to the damaged area of your knee cartilage.Once implanted into the damaged area, your cells detach from the membrane, combine with proteins in your knee cartilage, and form a durable repair tissue.You will begin a physician-prescribed rehabilitation program specifically designed for you.1. Suture fixation is not required.Patients who receive the MACI implant must follow a physician-prescribed rehabilitation program. The implantation membrane is trimmed by the treating surgeon to the size and shape of the defect, to ensure the damaged area is completely covered, and implanted cell-side down.Effectiveness of MACI in joints other than the knee has not been established.Safety and effectiveness of MACI in patients over the age of 55 years have not been established.MACI is contraindicated in patients with a known history of hypersensitivity to gentamicin, other aminoglycosides, or products of porcine or bovine origin. By continuing to use this website without changing your settings, you are agreeing to our use of cookies and to our collection of information. Saris D, Price A, Widuchowski W, et al. Consult your doctor if you have cancer in the area of the cartilage biopsy or implant as the safety of MACI is not known in those cases.Conditions that existed before your surgery, including meniscus tears, joint or ligament instability, or alignment problems should be evaluated and treated before or at the same time as the MACI implant.MACI has not been studied in patients younger than 18 or over 55 years of age.Common side effects include joint pain, tendonitis, back pain, joint swelling, and joint effusion.More serious side effects include joint pain, cartilage or meniscus injury, treatment failure, and osteoarthritis.This site is intended for United States residents only.©2020 Vericel Corporation. Consult the MACI is intended for autologous use and must only be administered to the patient for whom it was manufactured. MACI is the next generation of ACI Repair articular cartilage defects in the knee using a patient’s own cells MACI showed statistically significantly greater improvement over microfracture for pain relief and functional improvement ¹ produces a durable repair tissue able to fill the cartilage lesion When the cartilage is ready, the surgeon takes the cartilage implant and … MACI is also not indicated for use in patients who have undergone prior knee surgery in the past 6 months, excluding surgery to procure a biopsy or a concomitant procedure to prepare the knee for a MACI implant.MACI is contraindicated in patients who are unable to follow a physician-prescribed post-surgical rehabilitation program.The safety of MACI in patients with malignancy in the area of cartilage biopsy or implant is unknown. Use in patients with local inflammations or active infections in the bone, joint, and surrounding soft tissue should be temporarily deferred until documented recovery.The MACI implant is not recommended during pregnancy. All rights reserved. The MACI film is trimmed by your surgeon to match the size and shape of the damage, to ensure the damaged area is completely covered.It is not known whether MACI is effective in joints other than the knee. During your arthroscopy, a procedure to look inside your knee, your surgeon will take 2 to 3 pieces of healthy knee cartilage—each about the size of a Tic Tac ® —and send them to our state-of-the-art, FDA-licensed facility.

MACI is used for the repair of symptomatic cartilage damage of the adult knee.



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