2020 Apr;165(4):877-889. doi: 10.1007/s00705-020-04532-7. This paper highlights the current knowledge of molecular epidemiology, diagnosis, and pathogenesis of PEDV, as well as prevention and control measures against PEDV infection. The top illustration represents the organization of the PEDV genome. 2020 Apr;165(4):877-889. doi: 10.1007/s00705-020-04532-7. 2016 Dec 2;226:40-49. doi: 10.1016/j.virusres.2016.09.003. 2020 Jul 9;147:104378. doi: 10.1016/j.micpath.2020.104378.

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During the viral entry stage, trypsin increased the penetration of Vero-cell-attached PEDV by approximately twofold. Clinically, PEDV is very similar to TGEV, and laboratory tests are required to differentiate the viruses.

2020 Jul 13;143:105949. doi: 10.1016/j.envint.2020.105949. Porcine epidemic diarrhea virus (PEDV) is an enveloped and single-stranded RNA virus that belongs to the Coronaviridae family (Murphy et al., 1999, Egberink et al., 1988). Epub 2016 Sep 13.Virus Genes. Online ahead of print.Database (Oxford). Gene. Function i. Online ahead of print. The envelope contains three main viral proteins, spike (S, 180–220 kDa), membrane (M, 27–32 kDa) and small membrane(sM, 7 kDa) (Locker et al., 1992, Sang-Geon et al., 2003). doi: 10.1093/database/baaa063.Front Microbiol. 2016 Feb 1;13:19. doi: 10.1186/s12985-016-0465-y.Sun M, Ma J, Wang Y, Wang M, Song W, Zhang W, Lu C, Yao H.J Clin Microbiol. These polyproteins are proteolytically cleaved into 16 nsps comprising the replication and transcription complex (RTC) that first engages in the minus-strand RNA synthesis using genomic RNA.

2015 May;53(5):1484-92. doi: 10.1128/JCM.02898-14. The enteric disease of swine recognized in the early 1970s in Europe was initially described as "epidemic viral diarrhea" and is now termed "porcine epidemic diarrhea (PED)". These recent outbreaks and global re-emergence of PED require urgent attention and deeper understanding of PEDV biology and pathogenic mechanisms. The present study describes the mode of action of trypsin in enhancing PEDV infection in Vero cells during different stage of the virus life cycle. Soon thereafter, large-scale PED epidemics recurred through the pork industry in South Korea, Japan, and Taiwan.

Online ahead of print.Database (Oxford). The development of porcine epidemic diarrhea virus (PEDV) antibody-based assays is important for detecting infected animals, confirming previous virus exposure, and monitoring sow herd immunity. Schematic representations of PEDV genome organization and virion structure. Reviewed-Annotation score: -Protein inferred from homology i. Only the corresponding alignment of amino acid sequences of the N-terminal region containing hypervariable regions [26] is shown. PEDV binds pAPN via the spike protein. Schematic representations of PEDV genome organization and virion structure. The coronavirus referred to as PED virus (PEDV) was determined to be the etiologic agent of this disease in the late 1970s. Overview of the PEDV replication cycle. Solid lines indicate PEDV spreads that have already occurred between countries; dotted lines indicate PEDV spreads that are expected to happen eventually; dashed circular arrows denote genetic mutations or recombination events that lead to the emergence of the novel subtypes eCollection 2020.Liu D, Ge L, Wang Q, Su J, Chen X, Wang C, Huang K.Environ Int.

Genetic subgroups of PEDV were marked with different… More information about the virus and the disease is still necessary for the development of effective vaccines and control strategies. COVID-19 is an emerging, rapidly evolving situation. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.

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