The more cell types a cell can differentiate into, the greater its potency. In another case, human umbilical cord blood stem cells were converted into human neurons.Multipotent cells are found in many, but not all human cell types. They investigate the importance of cell dynamics for their development and homeostasis, but also for disorders of the vascular and of the nervous system. “Totipotency is a much more flexible state than the pluripotent state and its potential applications are extraordinary”, says Maria-Elena Torres-Padilla, who led the study. A 2C-like cell (green) is different from an embryonic stem cell (magenta) Pluripotent cells then continue to specialise and form the various tissues of the body through a process called cellular differentiation.For some years, it has been possible to re-programme differentiated cells into pluripotent ones, but not into totipotent cells. The work results as a collaboration between the two laboratories in the framework of the RISE1 programme of the EpiGeneSys EU Network of Excellence.These results provide new elements for the understanding of pluripotency and could increase the efficiency of reprogramming somatic cells to be used for applications in regenerative medicine. © MPI Münster / J. Müller-Keuker Easy to isolate and grow . © IGBMC / Maria-Elena Torres-Padilla A closer look revealed that CAF1 -already known for its role in the assembly of chromatin (the organised state of DNA)- is responsible for maintaining the pluripotent state by ensuring that the DNA is wrapped around histones.

© MPI Münster / J. Müller-Keuker The Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) is the largest French research unit involving the Institut National de Santé et de Recherche Médicale (Inserm), the Centre National de la Recherche Scientifique (CNRS) and the University of Strasbourg. Looking for the keys of totipotency Totipotency, Pluripotency and Nuclear Reprogramming - PubMed Mammalian development commences with the totipotent zygote which is capable of developing into … Scientists discover mechanism that may lead to more efficient reprogramming of somatic cellsWhile it is already possible to obtain in vitro pluripotent cells (i.e., cells capable of generating all tissues of an embryo) from any cell type, a team of researchers around Maria-Elena Torres-Padilla (Institute of Genetics and Molecular and Cellular Biology, Strasbourg) and Juanma Vaquerizas (Max Planck Institute for Molecular Biomedicine, Münster) have pushed the limits of science even further. Easy to isolate and grow. Since November 2012, the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG) supports CiM in the frame of the Excellence Initiative of the Federal and State Governments for five years. “The computational analysis of expression of repetitive elements is very challenging, since these are found many times in the genome”, says Juanma Vaquerizas. iPSCs could potentially have the same therapeutic implications and applications as ESCs but without the controversial use of embryos in the process, a topic of great bioethical debate. As an FP7 European Community-funded Network of Excellence, EpiGeneSys’s goals go further than simply funding a research project— the extensive training program is helping to build a bridge between the fields of epigenetics and systems biology and the public education mission communicates the science in an accessible and interesting fashion while awakening young pupils’ interest in research. Totipotent cells can form all the cell types in a body, plus the extraembryonic, or placental, cells. Mitalipov S(1), Wolf D. CiM-PhD student Rocio Enriquez-Gasca (center) and Max Planck research group leader Dr. Juanma Vaquerizas (right) Less ethical issues, less chance of immune rejection if taken from same patient.

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