x��Zˮ����+�6p9]�$A�$RAd��YY���������ԫ�Hqƛ�����z�:Uݔ�����3���0�ަ� �!B��w��|��|�����?N��C�Mn���hn����_������>�S��~�g;���ad�@OCY��#ed/��p��?�>��'�M��Bm�5�8&#�}{?�Ѣ�ip�E���>�78{�g㌧?�.�w?.oxc�+���v��������U^SW�O1�./f;0y��kwy�$���h9�̀ˬ�.L�є���2�~�Y[�G>Nd��n|g�/��[8�!�X~�Ƴ��x?ĩI���t��0�~�:����ռZ���%�u���ʓ�޽ӗi1�oEv�hf2��ę$�Q�1_�ufx����2D�����)W��H��1#�KY���FР�f��AZM���$�j&��u��*@ ���Ψv�� /:���q�,r�u��p�fW 7�h��a���bM:�+af���F/|�q+vՙ%#[���1���VH�?3�ɑsM��.�3�`�̨-d kbn��P�gA�=��%��e��-%��d,� Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent that inhibits cell division by blocking the polymerisation of tubulin. Storage condition: -20 ° C. Shipping: Ambient Temperature SDS: Download. stream Storage condition: Pradeep.Dhal@sanofi.com. 3.Warnung auf Dolastatin 10 Usually ships within 24 hours. We report a … … )� PRICE A dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody-drug conjugate (ADC). Convergent synthesis of hydrophilic monomethyl dolastatin 10 based drug linkers for antibody drug conjugation Kanwen Yang, Bo Chen, Diego A. Gianolio, James E. Stefano, Michelle Busch, Charlene Manning, Kim Alving, Richard C. Gregory, William H. Brondyk, Robert J. Miller, Pradeep K. Dhal* Sanofi Global R&D, 153 Second Avenue, Waltham, MA 02139, USA *Corresponding author: …

Third Party Contract Manufacturing (APIs and Excipients) Product Sourcing (APIs and Excipients) GDP Compliant Logistics; Securing of Supply Chains - 2nd Sources Name: Monomethyl Dolastatin 10.

Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor. [1,2,3] The family of auristatins are synthetic analogues of the antineoplastic natural product Dolastatin 10, ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates. Author information: (1)Sanofi Global R&D, 153 Second Avenue, Waltham, MA 02139, USA. 2 0 obj Catalog #: BP-23644. <> Formula: C41H66N6O6S. No items found! Monomethyl auristatin E Synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. QTY

Synonyms: Demethyldolastatin 10; Monomethylauristatin D; MMAD. CAS: 203849-91-6.

Monomethyl auristatin D (MMAD) is a potent tubulin inhibitor.Reproduction of any materials from the site is strictly forbidden without permission. ���(��RSQ*ۮ(��L����h�:h I�sʰ�1��945S��W�5� �����,���g[a-¹���HW�ظ_����æp����f&�K;j%�M r Das Antikörper-Wirkstoff-Konjugat (ADC) umfasst den monoklonalen Anti-CD30-Antikörper cAC10, der an das zytotoxische Mittel Monomethyl-Auristatin E (MMAE) konjugiert ist, ein synthetisches Analogon des Tubulin-Polymerisationsinhibitors Dolastatin 10 (110417-88-4). MW: 771.1. %PDF-1.5 Purity: 95%. Availability: In Stock. Ships within: 24 hours . Yang K(1), Chen B(1), Gianolio DA(1), Stefano JE(1), Busch M(1), Manning C(1), Alving K(1), Gregory RC(1), Brondyk WH(1), Miller RJ(1), Dhal PK(1). Convergent synthesis of hydrophilic monomethyl dolastatin 10 based drug linkers for antibody-drug conjugation. Ambient Temperature Product Description Catalog #: LSG420, 1 mg LSG421, 5 mg LSG422, 10 mg MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. %äüöß Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. UNIT Monomethyl Dolastatin 10.

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