As a result, normal blood production in the bone marrow is impaired and may shift to other organs, such as the spleen and liver, which can cause them to enlarge. Common MDS subgroups include ringed sideroblast positive, or RS+, and ringed sideroblast negative, or RS-.The majority of MDS patients, approximately 70%, fall into what are considered to be the lower risk groups at diagnosis, according to the International Prognostic Scoring System that takes into account the presence of a number of disease factors, such as cytopenias and cytogenetics, to assign relative risk of progression to AML and overall survival. Geron Corporation (Nasdaq: GERN) today announced that it will release its second quarter 2020 financial results after the market closes on Thursday, A Thank you for joining us for today’s conference call. The Company’s cash position reflects net proceeds of approximately $140 million from a public offering of securities in the second quarter. ET on Thursday, May 28, 2020 to discuss plans for the Phase 3 clinical trial in refractory MF, as well as an update on the IMerge Phase 3 clinical trial and first quarter financial results.Participants may access the conference call live via telephone by dialing domestically +1 (833) 513-0551 or internationally +1 (647) 689-4209. Many of these patients become dependent on red blood cell transfusions due to low hemoglobin. Geron is a late-stage clinical biopharmaceutical company focused on the development and potential commercialization of a first-in-class telomerase inhibitor, imetelstat, in hematologic myeloid malignancies. Key opinion leaders within hematologic myeloid malignancies reprised four presentations containing new clinical data and analyses related to imetelstat from the Virtual Edition of the EHA Annual Congress.

We are a focused organization with the expertise and insights to advance innovative new therapies. Net loss for the first six months of 2020 was $32.2 million, or $0.14 per share, compared to $24.3 million, or $0.13 per share, for the comparable 2019 period. Serial red blood cell transfusions can lead to elevated levels of iron in the blood and other tissues, which the body has no normal way to eliminate. Based on discussions with U.S. and European regulatory authorities, Geron believes the IMerge Phase 3 clinical trial, if successful, will support the registration of imetelstat in lower risk MDS.The Company expects its 2020 operating expense burn to range from $70 to $75 million. Ethics and proximity guide Gerdau’s stakeholder relations. Geron also provided an update on its ongoing IMerge Phase 3 clinical trial in lower risk MDS and reported revised fiscal year 2020 operating expense guidance.“We are very pleased to announce that following a productive meeting with the FDA, we plan to move forward with a randomized Phase 3 clinical trial in refractory MF,” said John A. Scarlett, M.D., Chairman and Chief Executive Officer. The Company continues to expect patient enrollment to be completed by the end of the first quarter of 2021, subject to potential future delays or interruptions associated with COVID-19. Based on current planning assumptions, the Company expects such funds to be sufficient for its operations into the second half of 2022 when top-line results for the IMerge Phase 3 clinical trial in lower risk MDS and completion of patient enrollment for the planned Phase 3 clinical trial in refractory MF are expected.

Geron Announces Plans for Imetelstat Phase 3 Clinical Trial in Myelofibrosis and Other Updates Also reported for the first time, 29% of the 38 patients were transfusion free for more than one year. In addition, other peripheral cytopenias, or low numbers of white blood cells and platelets, may cause life-threatening infections and bleeding. Early clinical data suggest imetelstat may have disease-modifying activity through the apoptosis of malignant stem and progenitor cells, which allows potential recovery of normal hematopoiesis. Under current planning assumptions, Geron expects to complete patient enrollment in the second half of 2022, to conduct an interim analysis in the first half of 2023 and to conduct a final analysis in the first half of 2024. The stock option has a 10-year term and vests over four years, with 12.5% of the shares underlying the option vesting on the six-month anniversary of commencement of employment and the remaining shares vesting over the following 42 months in equal installments of whole shares, subject to continued employment with Geron through the applicable vesting dates. The stock option was granted on July 15, 2020 at an exercise price of $2.04 per share, which is equal to the closing price of Geron common stock on the date of grant. These forward-looking statements involve risks and uncertainties that can cause actual results to differ materially from those in such forward-looking statements. To minimize potential registration and access delays, Geron has implemented Direct Event, which allows participants to pre-register online using the following link, Under current assumptions, the Company expects top-line results to be available in the second half of 2022.

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