Epub 2020 Jun 19.Annweiler C, Cao Z, Wu Y, Faucon E, Mouhat S, Kovacic H, Sabatier JM.Infect Disord Drug Targets.

Online ahead of print.Park SJ, Yu KM, Kim YI, Kim SM, Kim EH, Kim SG, Kim EJ, Casel MAB, Rollon R, Jang SG, Lee MH, Chang JH, Song MS, Jeong HW, Choi Y, Chen W, Shin WJ, Jung JU, Choi YK.mBio.



The SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally.

2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0.J Clin Med. Transcriptomic analysis following SARS-CoV-2 infection revealed a robust induction of chemokines and cytokines with little type I/III interferon signaling, similar to that observed amongst human COVID-19 pulmonary infections. Free PMC article This site needs JavaScript to work properly. Melbourne biotech company Cynata Therapeutics has received approval to enrol two dozen seriously ill COVID-19 patients in a NSW trial of its stem cell drug candidate.Twelve COVID-19 patients with compromised lung function will receive infusions of Cynata's Cymerus mesenchymal stem cells treatment in addition to their normal care, while the other 12 will just receive the standard course of treatment.Researchers will then see after a week if the patients who received the Cymerus treatment have better oxygen levels in their blood than those in the control group.Cynata said it was also assessing opportunities to expand the COVID-19 trial to other jurisdictions, as the Cymerus treatment has shown promise in treating conditions that can arise from severe COVID-19 infections.The study will be conducted in NSW centres in collaboration with the Cerebral Palsy Alliance Research Institute and investigators from the COVID-19 Stem Cell Treatment Group.Cynata's lead product candidate is a stem cell treatment for graft-versus-host disease, a complication that sometimes arises after organ transplants.By 1340 AEDT, Cynata shares had jumped 14.5 per cent to 75 cents.Joe Biden decided he didn't have to choose a leftwing progressive.
Clipboard, Search History, and several other advanced features are temporarily unavailable. Free PMC article Name must be less than 100 characters 2020 May 17. doi: 10.2174/1871526520666200518073329.

COVID-19 is an emerging, rapidly evolving situation. doi: 10.1128/mBio.01114-20.Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y.Mil Med Res. Please enable it to take advantage of the complete set of features!

Together, these data demonstrate that hPSC-derived lung cells infected by SARS-CoV-2 can model human COVID-19 disease and provide a valuable resource to screen for FDA-approved drugs that might be repurposed and should be considered for COVID-19 clinical trials. Pre- or post-treatment with these drugs at physiologically relevant levels decreased SARS-CoV-2 infection of hPSC-derived lung organoids.

Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S.Cell Stem Cell. Cynata Therapeutics Limited Level 3, 62 Lygon Street, Carlton, Victoria 3053, Australia PO Box 7165, Hawthorn North, Victoria 3122 T: + 613 9824 5254 F: + 613 9822 7735 E: info@cynata.com ABN - 98 104 037 372 ASX ANNOUNCEMENT 8 May 2020 Cynata Receives Ethics Approval to Commence Clinical Trial in COVID- 19 and Clinical Development Update The lung organoids, particularly aveolar type II cells, express ACE2 and are permissive to SARS-CoV-2 infection. Here's whyDisability care agency banned after degrading death of Adelaide woman Ann Marie Smith
The SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally. We performed a high throughput screen using hPSC-derived lung organoids and identified FDA-approved drug candidates, including imatinib and mycophenolic acid, as inhibitors of SARS-CoV-2 entry. 2020 Apr 15;9(4):1131. doi: 10.3390/jcm9041131.Nat Rev Mol Cell Biol. 2020 Jul 2;27(1):125-136.e7. There is an urgent need to create novel models to study SARS-CoV-2 using human disease-relevant cells to understand key features of virus biology and facilitate drug screening. Cold Spring Harbor Laboratory Search for the very latest Stockhead news and views on Cynata Therapeutics - CYP. Get the best stories in the world all in one place with Disney+Cash Rate Cut: Are You Getting The Best Home Loan Deal? Cynata also has strong pre-clinical study results in sepsis and cytokine release syndrome, which along with ARDS are common hallmarks of severe Covid-19 cases. The ACTIV public-private partnership has evaluated hundreds of available therapeutic agents with potential application for COVID-19, prioritized the most promising candidates, designed and harmonized four adaptive master protocols for ACTIV clinical trials, and selected numerous NIH-supported networks to launch these clinical trials to test prioritized therapeutic candidates. The latest news about ASX-listed small and micro cap stocks published daily by Australia’s best business journalists. Company Overview ... Cynata Therapeutics Tianhe Stem Cell Biotechnologies Biostar Stem Cell Research Institute COVID-19 is caused by the SARS-CoV-2 coronavirus, which is approximately 82% identical to the severe acute respiratory syndrome related coronavirus (SARS-CoV) that … Cold Spring Harbor Laboratory As primary SARS-CoV-2 infection is respiratory-based, we developed a lung organoid model using human pluripotent stem cells (hPSCs) that could be adapted for drug screens.

It focuses on therapeutic stem cell platform technology. The company is encouraged by pre-clinical modelling and has regulatory approval to …




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